Chen K, Shumack S
St George Dermatology and Skin Cancer Centre, Kogarah, NSW, Australia.
Clin Exp Dermatol. 2003 Nov;28 Suppl 1:10-2. doi: 10.1046/j.1365-2230.28.s1.4.x.
Bowen's disease (BD; intraepithelial squamous cell carcinoma) is a challenging condition to treat because lesions, which can be multiple, are often located at sites that heal poorly, such as the shin. The disease is usually persistent and progressive and appears as an enlarging, demarcated erythematous plaque. Two elderly female patients with Bowen's disease of the lower leg are presented. Imiquimod 5% cream was applied in a cycle of three times weekly for 3 weeks followed by a 4-week rest period. The treatment was successful after a second cycle of therapy, with both cases clinically clear at 2- and 3-month follow-up visits.
鲍温病（BD；上皮内鳞状细胞癌）是一种难以治疗的疾病，因为病变可能为多发，且常位于愈合不良的部位，如下肢胫部。该疾病通常持续进展，表现为边界清晰的红斑逐渐扩大。本文介绍了两名患有小腿鲍温病的老年女性患者。采用5%咪喹莫特乳膏，每周外用3次，连用3周，随后休息4周。在第二个疗程后治疗取得成功，两名患者在2个月和3个月的随访时临床症状均消失。
