Ferguson Thomas A, Stuart Patrick M, Herndon John M, Griffith Thomas S
Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, MO 63110, USA.
Immunol Rev. 2003 Jun;193:111-23. doi: 10.1034/j.1600-065x.2003.00042.x.
Antigen-specific unresponsiveness (or tolerance) has always been an important area of research. Interest in the fate of apoptotic cells and their ability to tolerize has revived interest in some of the older models involving hapten-modified self. Recently, we have examined the mechanisms by which intravenous injection of trinitrophenol-coupled spleen cells leads to systemic tolerance. These studies have revealed an important role for Fas/Fas ligand interactions, caspases, CD40/CD40L, and regulatory CD4+ and CD8+ T cells. Extension of these studies to peripheral deletion of T-cell antigen receptor transgenic T cells has shown that deletion and active regulation of immune responses may be important mechanisms for the control of potentially damaging autoimmune responses.
抗原特异性无反应性（或耐受性）一直是一个重要的研究领域。对凋亡细胞的命运及其诱导耐受能力的关注，重新唤起了人们对一些涉及半抗原修饰自身的早期模型的兴趣。最近，我们研究了静脉注射三硝基苯酚偶联脾细胞导致全身耐受的机制。这些研究揭示了Fas/Fas配体相互作用、半胱天冬酶、CD40/CD40L以及调节性CD4+和CD8+T细胞的重要作用。将这些研究扩展到T细胞抗原受体转基因T细胞的外周缺失，结果表明免疫反应的缺失和主动调节可能是控制潜在有害自身免疫反应的重要机制。
