Lewis J H
Am J Vet Res. 1976 May;37(5):601-5.
Results of blood coagulation and hematologic studies on 6 goats, each tested 3 times, were compared to the values seen in persons. Special blood platelet studies were done on an additional goat. Blood coagulation values in the goats and in persons were similar, with these exceptions: In the goat, activated partial thromboplastin time was shorter and thrombin time was longer; one-stage assays of factors V, VIII, and IX were very high, and platelets aggregated poorly epinephrine and ristocetin. Both platelets and erythrocytes were small. On scanning electron microscopy, the erythrocytes appeared as flat disks or triangles, occasionally having a dimpled center, compared to the deeply dimpled doughnut shape of the larger human erythrocytes. Osmotic fragility of these small erythrocytes was greater than that of their human counterparts. By transmission electron microscopy of ultrathin sections of goat buffy coat, platelets had fine structures similar to those of human platelets. Unlike in human platelets, most of the dense bodies in goat platelets were surrounded by clear vacuoles. Biochemical studies showed higher than human levels of phosphorus, chloride, sodium, alkaline phosphatase, and serum glutamic oxaloacetic transaminase.
对6只山羊进行了凝血和血液学研究，每只山羊测试3次，并将结果与人类的相关数值进行比较。另外对1只山羊进行了特殊的血小板研究。山羊和人类的凝血值相似，但有以下例外情况：山羊的活化部分凝血活酶时间较短，凝血酶时间较长；因子V、VIII和IX的一期检测值非常高，血小板对肾上腺素和瑞斯托霉素的聚集能力较差。血小板和红细胞都较小。扫描电子显微镜观察显示，与人类较大的红细胞呈深深凹陷的甜甜圈形状相比，山羊的红细胞呈扁平圆盘状或三角形，偶尔中心有凹陷。这些小红细胞的渗透脆性大于人类红细胞。通过对山羊血沉棕黄层超薄切片的透射电子显微镜观察，发现山羊血小板的精细结构与人类血小板相似。与人类血小板不同的是，山羊血小板中的大多数致密体被透明空泡包围。生化研究表明，山羊体内磷、氯、钠、碱性磷酸酶和血清谷氨酸草酰乙酸转氨酶的水平高于人类。
