Li Gen-wu, Wu Ling-da, Zhu Yi
Department of Gastroerology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 May;23(5):483-4.
To observe changes of plasma neuropeptide Y(NPY) level in ascitic patients with decompensated cirrhosis pre- and post-treatment, there fore to understand the correlation of NPY with liver function and ascitic formation.
NPY plasma levels in 20 patients with decompensated cirrhosis and ascites were detected by radioimmunological assay.
Plasma NPY levels in patients with cirrhotic ascites were significantly lower than those in normal subjects(P < 0.01) in spite of the increases of NPY after ascites decreased (P < 0.01), which were still lower than those in normal subjects(P < 0.01).
Decreased plasma NPY levels are correlated with the severity of liver damage and may be responsible for the changes of hemodynamics and ascitic formation in patients with liver cirrhosis.
观察失代偿期肝硬化腹水患者治疗前后血浆神经肽Y（NPY）水平的变化，以了解NPY与肝功能及腹水形成的相关性。
采用放射免疫分析法检测20例失代偿期肝硬化腹水患者的血浆NPY水平。
肝硬化腹水患者血浆NPY水平显著低于正常对照者（P<0.01），腹水减少后NPY水平有所升高（P<0.01），但仍低于正常对照者（P<0.01）。
血浆NPY水平降低与肝损害严重程度相关，可能参与了肝硬化患者血流动力学改变及腹水的形成。
