Ordiales Fernández J J, Fernández Moya A, Linares Rodríguez A, Colubi Colubi L, Nistal de Paz F, Allende González A, Rodrigo Sáez L
Sección de Neumología, Hospital de León.
Rev Esp Enferm Dig. 1996 Mar;88(3):197-201.
The study of the disturbances of arterial gases and the changes in the arterial pH which are present in patients with liver cirrhosis and ascites and their modification after the disappearance of ascites by treatment.
Open study,with protocol and prospective, to evaluate the changes in measurement of the arterial gases and acid-base, parameters in matching groups of patients.
We include 24 patients, 15 males and 9 females, without preliminary or cardio-respiratory pathology age range between 37 and 77 years, average of 56.8 years, all of them diagnosed of liver cirrhosis of different etiologies and with important ascites. All of them finished the study.
In patients with liver cirrhosis and ascites a fall in the PaO2 and in the PaCO2 was demonstrated the pH in the upper limit of the normality compatible with hypoxemia and respiratory alkalosis. After the disappearance of the ascites, a significant improvement in the PaO2 (p < 0.05), without any changes in the PaCO2 and pH values was apparent.
In patients with liver cirrhosis, with or without ascites, hyperventilation is present, that can be multifactorial in origin, but which really has an unknown cause. We have found no relationship with the circulating levels of progesterone.
研究肝硬化腹水患者存在的动脉血气紊乱及动脉pH值变化，以及治疗后腹水消失时这些指标的改变。
开放性研究，采用方案设计和前瞻性研究，评估患者配对组中动脉血气和酸碱参数测量值的变化。
纳入24例患者，男性15例，女性9例，无原发性或心肺疾病，年龄在37至77岁之间，平均56.8岁，均诊断为不同病因的肝硬化且有大量腹水。所有患者均完成研究。
肝硬化腹水患者PaO₂和PaCO₂下降，pH值在与低氧血症和呼吸性碱中毒相符的正常上限。腹水消失后，PaO₂有显著改善（p < 0.05），而PaCO₂和pH值无变化。
肝硬化患者无论有无腹水均存在过度通气，其原因可能是多因素的，但真正病因不明。我们未发现其与孕酮循环水平有关。
