Brinberg L S, Iudina O D, Grodzenskaia S F, Korchagin V B, Vagina I M
Antibiotiki. 1976 Jan;21(1):27-30.
The effect of n-propyl alcohol on biosynthesis of erythromycin and the dynamics of the precursor consumption were studied with the method of gas-liquid chromatography. It was shown that neither the optimal concentration of the precursor, nor its stimulating effect on different media correlated. n-Propyl alcohol was used not only for the antibiotic biosynthesis but also according to other metabolic path-ways and in addition its evaporation from the medium was registered. During the first period of the fermentation n-propyl alcohol suppressed the antibiotic biosynthesis.
采用气液色谱法研究了正丙醇对红霉素生物合成的影响以及前体消耗的动力学。结果表明，前体的最佳浓度与其在不同培养基上的刺激作用均无相关性。正丙醇不仅用于抗生素生物合成，还参与其他代谢途径，此外还记录到其从培养基中的挥发情况。在发酵的第一阶段，正丙醇抑制了抗生素的生物合成。
