Kuznetsov L E
Antibiot Med Biotekhnol. 1985 Jul;30(7):485-9.
The effect of temperature variation in cultivation of the erythromycin-producing organism on accumulation of the antibiotic in the fermentation broth was studied during the growth and development of the microbial population. None of the tested processes of erythromycin biosynthesis with one-stage and two-stage variation of the temperature conditions or their short-term variation provided a significant increase in the antibiotic yield. It was shown that with an increase in the temperature from 33 to 37 degrees C in the 72-120-hour fermentation process, the rate of the antibiotic accumulation after 24 hours of the increased temperature effect did not decrease, while in the 120-hour fermentation process the increased temperature had an insignificant effect on erythromycin accumulation even within the subsequent 24 hours of the culture growth.
在微生物群体的生长和发育过程中，研究了培养产红霉素生物体时温度变化对发酵液中抗生素积累的影响。在温度条件进行单阶段和两阶段变化或短期变化的红霉素生物合成测试过程中，均未使抗生素产量显著提高。结果表明，在72 - 120小时的发酵过程中，温度从33℃升高到37℃，温度升高作用24小时后抗生素积累速率并未降低，而在120小时的发酵过程中，即使在培养物生长的后续24小时内，温度升高对红霉素积累的影响也不显著。
