[Effect of a temperature regimen on erythromycin biosynthesis].

The effect of temperature variation in cultivation of the erythromycin-producing organism on accumulation of the antibiotic in the fermentation broth was studied during the growth and development of the microbial population. None of the tested processes of erythromycin biosynthesis with one-stage and two-stage variation of the temperature conditions or their short-term variation provided a significant increase in the antibiotic yield. It was shown that with an increase in the temperature from 33 to 37 degrees C in the 72-120-hour fermentation process, the rate of the antibiotic accumulation after 24 hours of the increased temperature effect did not decrease, while in the 120-hour fermentation process the increased temperature had an insignificant effect on erythromycin accumulation even within the subsequent 24 hours of the culture growth.