Listvinova S N, Dmitrieva S V, Zaslavskaia P L, Orlova N V
Antibiotiki. 1983 Mar;28(3):177-87.
The effect of erythromycin on the growth, morphogenesis and antibiotic production capacity of the organism producing it or Str. erythreus was studied. Erythromycin was added to the medium in concentrations comparable to the productivity of the organism. It was shown that at the cell level Str. erythreus was highly resistant to its own antibiotic. Still, erythromycin had a significant effect on the developmental cycle of the culture. It inhibited the growth of the mycelium capable of the antibiotic production and induced an increase in reproduction. On long-term subculturing or in the presence of erythromycin the culture showed a pronounced tendency for fragmentation similar to that in proactinomycetes, whereas under the usual conditions the mycelial growth was not disturbed. However, the structure of the septa in Str. erythreus is typical of the streptomycetes. It is concluded that Str. erythreus occupies an intermediate position between Nocardia and Streptomyces.
研究了红霉素对产生它的生物体或红色链霉菌的生长、形态发生和抗生素生产能力的影响。将红霉素以与生物体生产力相当的浓度添加到培养基中。结果表明，在细胞水平上，红色链霉菌对其自身的抗生素具有高度抗性。然而，红霉素对培养物的发育周期有显著影响。它抑制了能够产生抗生素的菌丝体的生长，并诱导繁殖增加。在长期传代培养或存在红霉素的情况下，培养物表现出明显的碎片化倾向，类似于原放线菌，而在通常条件下菌丝体生长不受干扰。然而，红色链霉菌中隔膜的结构是链霉菌的典型结构。得出的结论是，红色链霉菌在诺卡氏菌和链霉菌之间占据中间位置。
