Geĭtman I Ia, Kivman G Ia
Antibiotiki. 1976 Apr;21(4):361-4.
The effect of cymotrypsin on excretion of penicillin, methicillin, oxacillin, streptomycin and gentamycin with urine including the kidney clearance was studied on rabbits. It was found that the enzyme introduced intramuscularly in a dose of 20 mg/kg increased excretion of penicillin, methicillin, oxacillin and gentamycin by 37, 24, 26 and 16 per cent respectively. The only exclusion was streptomycin. Chymotrypsin increased the kidney clearance of penicillin, methicillin, oxacillin, streptomycin and gentamycin by 1.7, 1.9, 2.2, 1.2 and 1.5 times respectively.
在兔子身上研究了糜蛋白酶对青霉素、甲氧西林、苯唑西林、链霉素和庆大霉素随尿液排泄包括肾脏清除率的影响。发现以20mg/kg的剂量肌肉注射该酶后，青霉素、甲氧西林、苯唑西林和庆大霉素的排泄量分别增加了37%、24%、26%和16%。唯一的例外是链霉素。糜蛋白酶使青霉素、甲氧西林、苯唑西林、链霉素和庆大霉素的肾脏清除率分别提高了1.7倍、1.9倍、2.2倍、1.2倍和1.5倍。
