用含脱矿骨基质颗粒的硫酸钙微球治疗大的骨缺损的愈合情况。

Healing of large defects treated with calcium sulfate pellets containing demineralized bone matrix particles.

作者信息

Urban Robert M, Turner Thomas M, Hall Deborah J, Infanger Susan, Cheema N, Lim T H

机构信息

Department of Orthopedic Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill, USA.

出版信息

Orthopedics. 2003 May;26(5 Suppl):s581-5. doi: 10.3928/0147-7447-20030502-11.

DOI:10.3928/0147-7447-20030502-11

PMID:12755230

Abstract

Calcium sulfate (OsteoSet, Wright Medical Technology, Inc, Arlington, Tenn) and calcium sulfate/demineralized bone matrix (DBM) pellets (OsteoSet DBM, Wright Medical Technology, Inc) have been evaluated preclinically in a bilateral medullary defect model of a canine humerus. In this model, both short (6 week) and long (26 week) time points have been evaluated. An analysis of bone response to the pellets was conducted using radiological, histological, mechanical, and quantification techniques. The calcium sulfate/DBM pellets exhibited more rapid trabecular bone remodeling as demonstrated by the absence of the ringlet bone structure typically seen with calcium sulfate pellets. We concluded that calcium sulfate and calcium sulfate/DBM pellets are both effective bone graft substitutes.

摘要

硫酸钙（OsteoSet，赖特医疗技术公司，田纳西州阿灵顿）和硫酸钙/脱矿骨基质（DBM）颗粒（OsteoSet DBM，赖特医疗技术公司）已在犬肱骨双侧髓腔缺损模型中进行了临床前评估。在该模型中，对短期（6周）和长期（26周）时间点均进行了评估。使用放射学、组织学、力学和量化技术对颗粒的骨反应进行了分析。硫酸钙/DBM颗粒表现出更快的小梁骨重塑，这表现为通常在硫酸钙颗粒中可见的小环骨结构的缺失。我们得出结论，硫酸钙和硫酸钙/DBM颗粒都是有效的骨移植替代物。