Hausen B M, Schulz K H
Arch Dermatol Res (1975). 1976 Apr 21;255(2):111-21. doi: 10.1007/BF00558518.
Experimental and chemical studies in guinea pigs on contact allergy caused by Chrysanthemum indicum L. (Chrysanthemum of the florists) led to the isolation of several sesquiterpene lactones. From the crude extract of dried flowers 12 fractions were obtained of which four gave strong reactions on epicutaneous application to guinea pigs sensitized with an extract of C. indicum L. One of these allergens was identified as a sesquiterpene lactone of the guaianolide type. It is identical to Arteglasin-A derived from Artemisia douglasiana Bess. The occurrence of Arteglasin-A in Chrysanthemum indicum L. as well as its allergenic properties are described forthe first time. These findings give rise to the assumption that the other, as yet unidentified sesquiterpene lactones of this flower also belong to the guaianolide type.
对豚鼠进行的关于由野菊花（花店售卖的菊花）引起的接触性过敏的实验和化学研究，导致分离出了几种倍半萜内酯。从干花的粗提取物中获得了12个馏分，其中4个在对用野菊花提取物致敏的豚鼠进行表皮涂抹时产生了强烈反应。这些过敏原之一被鉴定为愈创木内酯型倍半萜内酯。它与从道格拉斯蒿中提取的青蒿酯A相同。首次描述了青蒿酯A在野菊花中的存在及其致敏特性。这些发现引发了这样一种假设，即这种花中其他尚未鉴定的倍半萜内酯也属于愈创木内酯型。
