Pieri M, Pieri L, Saner A, Da Prada M, Haefely W
Arch Int Pharmacodyn Ther. 1975 Sep;217(1):118-30.
Drug-induced rotational behaviour was studied in two groups of rats with differing chemical lesion of the right medial forebrain bundle (MFB). 6-hydroxydopamine (6-OH-DA), 3.5 mug, injected in one group, induced a marked lowering of dopamine (DA) and noradrenaline (NA) in the right hemiforebrain. 5,6-Dihydroxytryptamine (5,6-HT), 10 mug, injected in a second group, produced a profound and long-lasting depletion of 5-hydroxytryptamine (5-HT) and DA, but not of NA. Rotational behaviour induced in both groups by DA receptor agonists (apomorphine, piribedil, L-DOPA, ergometrine, ergocornine, 2-bromo-alpha-ergocryptine, ergocristine, methylergometrine) and agents releasing DA (d-methamphetamine, methylphenidate) were qualitatively identical and quantitatively very similar, suggesting a minor role of 5-HT striatal terminals in these experimental conditions. LSD induced contralateral rotation by direct stimulation of the DA receptor, while L-5-hydroxy-tryptophan (L-5HTP) was inactive.
在两组右侧内侧前脑束（MFB）化学损伤不同的大鼠中研究了药物诱导的旋转行为。一组注射3.5微克6-羟基多巴胺（6-OH-DA），导致右侧半脑多巴胺（DA）和去甲肾上腺素（NA）显著降低。另一组注射10微克5,6-二羟基色胺（5,6-DHT），导致5-羟色胺（5-HT）和DA深度且持久地耗竭，但NA未受影响。DA受体激动剂（阿扑吗啡、匹罗卡品、左旋多巴、麦角新碱、麦角柯宁碱、2-溴-α-麦角隐亭、麦角嵴亭、甲基麦角新碱）和释放DA的药物（d-甲基苯丙胺、哌醋甲酯）在两组中诱导的旋转行为在性质上相同，在数量上非常相似，这表明在这些实验条件下5-HT纹状体终末的作用较小。LSD通过直接刺激DA受体诱导对侧旋转，而L-5-羟色氨酸（L-5HTP）无活性。
