Krementz E T, Sutherland C M, Carter R D, Ryan R F
Ann Surg. 1976 May;183(5):533-42. doi: 10.1097/00000658-197605000-00010.
Malignant melanoma in the American Black is an uncommon disease. Scattered reports have appeared in the literature indicating a somewhat different behavior and distribution from melanoma in the White patient. The last published report prior to the organization of the Tumor Registry at Charity Hospital of Louisiana on melanoma in the Black was in 1948 by Muelling when 28 cases were reported. From 1948 through 1974, 96 additional patients have been recorded in the Charity Hospital Registry which represents the largest reported experience in the American Literature. The average age at diagnosis is 57.8 years as opposed to 53 years for White patients observed over the same time period. The ratio by sex is essentially equal in Blacks. The disease usually presents on the palmar or plantar surfaces of the hands or feet in the Black. In the registry data 51% occurred on the lower limb, 11% on the upper limb, 6% on the trunk, 6% on the genitalia, 1% on the head or neck, 13% were of extradermal origin, and 10% had unknown primary sites. The 5-year cumulative survival for all Black patients in this series is 27%. In contrast to the poor overall survival, a 78% 5-year survival has been achieved in Stage I patients treated with perfusion, wide excision, and regional lymph node dissection.
美国黑人中的恶性黑色素瘤是一种罕见疾病。文献中已有零星报道表明，其行为和分布与白人患者的黑色素瘤有所不同。在路易斯安那慈善医院肿瘤登记处成立之前，关于黑人黑色素瘤的最后一篇发表报告是1948年穆林撰写的，当时报告了28例病例。从1948年到1974年，慈善医院登记处又记录了96例患者，这是美国文献中报道的最大规模经验。诊断时的平均年龄为57.8岁，而同期观察的白人患者为53岁。黑人中的性别比例基本相等。这种疾病在黑人中通常出现在手或脚的手掌或足底表面。在登记数据中，51%发生在下肢，11%发生在上肢，6%发生在躯干，6%发生在生殖器，1%发生在头部或颈部，13%为皮外起源，10%原发部位不明。该系列中所有黑人患者的5年累积生存率为27%。与总体生存率较差形成对比的是，接受灌注、广泛切除和区域淋巴结清扫治疗的I期患者5年生存率达到了78%。
