Krementz E T, Feed R J, Coleman W P, Sutherland C M, Carter R D, Campbell M
Ann Surg. 1982 May;195(5):632-45. doi: 10.1097/00000658-198205000-00013.
Acral lentiginous melanoma (ALM) is the fourth clinicopathologic variant of malignant melanoma. It occurs on volar surfaces of hands and feet, subungual sites, and fingers or toes. It is characterized by slow lentiginous radial growth and central plaque-like thickening, heavily pigmented tumor cells, markedly thickened papillary dermis, and diffuse reticular infiltration. Lesions are unusually large and, in most cases, thick and ulcerated. There were 180 patients with acral melanoma (AM), which includes 67 in whom the specific features of ALM could be documented. One hundren sixty had primary lesions on ;the foot, and 20 occurred on the hand. There were 104 men and 76 women. There were 41 black patients and 139 whites. Five-year survivals following all modalities of therapy in 122 patients with Stage I acral melanoma is 63% for planter/palmar lesions, 58% for subungual lesions, and 27% for skin of digits. For the subgroup of Stage I patients with ALM treated by surgery and regional chemotherapy by perfusion, the five-year survival for all sites is 72% and 56% at 10 and 15 years, respectively. Survival in ALM is essentially the same as for all AM lesions.
肢端雀斑样痣性黑色素瘤（ALM）是恶性黑色素瘤的第四种临床病理亚型。它发生于手掌、足底、甲下部位以及手指或脚趾。其特征为缓慢的雀斑样放射状生长和中央斑块样增厚，肿瘤细胞色素沉着明显，乳头真皮显著增厚，以及弥漫性网状浸润。病变通常较大，且在大多数情况下较厚并伴有溃疡。有180例肢端黑色素瘤（AM）患者，其中67例可记录到ALM的特定特征。160例原发损害位于足部，20例发生于手部。男性104例，女性76例。黑人患者41例，白人患者139例。122例I期肢端黑色素瘤患者接受所有治疗方式后的5年生存率，足底/手掌损害为63%，甲下损害为58%，手指皮肤损害为27%。对于接受手术和区域灌注化疗治疗的I期ALM患者亚组，所有部位的5年生存率在10年和15年分别为72%和56%。ALM的生存率与所有AM损害基本相同。
