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5岁以下儿童意外摄入非处方药物。

Unintentional ingestion of over the counter medications in children less than 5 years old.

作者信息

Chien C, Marriott J L, Ashby K, Ozanne-Smith J

机构信息

Department of Pharmacy Practice, Victorian College of Pharmacy, Monash University, Melbourne, Victoria 3052, Australia.

出版信息

J Paediatr Child Health. 2003 May-Jun;39(4):264-9. doi: 10.1046/j.1440-1754.2003.00148.x.

Abstract

OBJECTIVE

Childhood ingestion of medications remains a substantial problem. Medication available over the counter (OTC) is widely used and has significant toxicity. The present study aims to investigate the nature and extent of unintentional ingestion of OTC medication in children < 5 years old in Victoria, Australia, during the period 1996-2000, in order to highlight critical factors.

METHODS

Numbers of enquiries relating to unintentional ingestion of OTC medication in children < 5 years old and medication types were obtained from the Victorian Poisons Information Centre for 1998-2000. Emergency Department presentations involving poisoning of children < 5 years old, the medication types and subsequent admissions were obtained from the Victorian Emergency Minimum Dataset for 1996-2000.

RESULTS

Numbers of enquiries and Emergency Department attendances for poisoning were substantially higher for OTC medication than for prescription medication; however, a lower proportion of cases involving ingestion of OTC medication (24.8%) required hospital admission during the study period compared with cases involving ingestion of prescription medications (33.8%). Overall, the peak incidence was at 2 years of age, with a slight male over-representation. Paracetamol and cough/cold preparations were the most common agents.

CONCLUSIONS

The causes of unintentional ingestion of OTC medications by children might include lack of child-resistant closure (CRC), inadequate design of CRC, attitudes concerning the toxicity of OTC medications, or lack of vigilance by parents and carers in the storage and administration of OTC medications. Consideration should be given to restricting sales of toxic OTC medications to pharmacies, and increasing counselling of consumers concerning the toxicity and safe storage of OTC medications and the correct usage of CRC. The adequacy of CRC design and OTC medications warranting CRC should be reviewed by the relevant authorities.

摘要

目的

儿童误服药物仍是一个严重问题。非处方(OTC)药使用广泛且具有显著毒性。本研究旨在调查1996 - 2000年期间澳大利亚维多利亚州5岁以下儿童非故意误服OTC药物的性质和程度,以突出关键因素。

方法

从维多利亚州毒物信息中心获取1998 - 2000年5岁以下儿童非故意误服OTC药物的咨询数量及药物类型。从维多利亚州急诊最低数据集获取1996 - 2000年涉及5岁以下儿童中毒的急诊科就诊情况、药物类型及后续住院情况。

结果

OTC药物中毒的咨询数量和急诊科就诊人数显著高于处方药;然而,在研究期间,与误服处方药的病例(33.8%)相比,误服OTC药物的病例需要住院治疗的比例较低(24.8%)。总体而言,发病高峰年龄为2岁,男性略多。对乙酰氨基酚和止咳/感冒药是最常见的药物。

结论

儿童非故意误服OTC药物的原因可能包括缺乏儿童安全瓶盖(CRC)、CRC设计不完善、对OTC药物毒性的态度、或家长及护理人员在OTC药物储存和给药方面缺乏警惕性。应考虑将有毒OTC药物的销售限制在药店,并加强对消费者关于OTC药物毒性、安全储存及CRC正确使用的咨询。相关当局应审查CRC设计的充分性以及需要CRC的OTC药物。

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