Rammelsberg Peter, LeResche Linda, Dworkin Samuel, Mancl Lloyd
Universitaetsklinikum, Poliklinik fuer Zahnaerztliche Prothetik University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
J Orofac Pain. 2003 Winter;17(1):9-20.
To investigate the course of myofascial pain defined by Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) over a period of 5 years, and to identify prognostic factors from baseline data.
Subjects were 155 consecutive patients and 80 community cases identified from an age-stratified representative population sample; all met the primary selection criterion of reporting pain in the temporomandibular joint (TMJ) or masticatory muscles. The 2 groups were combined to yield a total sample of 235 subjects (50 male, 185 female; mean age = 39 years). Subjects were evaluated at baseline, 1 year, 3 years, and 5 years by trained examiners using standardized, reliable methods. Psychological and behavioral factors were assessed by self report.
According to RDC/TMD criteria, 50 (31%) of the 165 subjects presenting with myofascial pain (MFP) at baseline continued to have their disorder over a period of 5 years; 55 (33%) remitted, and 60 (36%) were recurrent cases. Bivariate statistics and multivariate logistic regression analyses indicated that baseline pain frequency, number of painful palpation sites, and total number of body sites with pain were significant predictors of persistent vs remitted and recurrent cases. No predictors that distinguished remission vs recurrence could be identified. Thirty subjects from the 70 without a diagnosis of MFP at baseline developed a new MFP. A high baseline somatization score (without pain items) was a significant risk factor for onset of MFP.
Muscle disorders classified by RDC/TMD are predominantly chronic or fluctuating pain conditions, with a modest probability (31%) of remission.
调查符合颞下颌关节紊乱病研究诊断标准(RDC/TMD)的肌筋膜疼痛在5年期间的病程,并从基线数据中识别预后因素。
研究对象为155例连续患者以及从按年龄分层的代表性人群样本中确定的80例社区病例;所有患者均符合报告颞下颌关节(TMJ)或咀嚼肌疼痛的主要入选标准。将两组合并,得到235名受试者的总样本(50名男性,185名女性;平均年龄 = 39岁)。由经过培训的检查人员在基线、1年、3年和5年时使用标准化、可靠的方法对受试者进行评估。通过自我报告评估心理和行为因素。
根据RDC/TMD标准,165例在基线时出现肌筋膜疼痛(MFP)的受试者中,有50例(31%)在5年期间持续患有该疾病;55例(33%)缓解,60例(36%)为复发病例。双变量统计和多变量逻辑回归分析表明,基线疼痛频率、疼痛触诊部位数量以及身体疼痛部位总数是持续性与缓解性及复发病例的重要预测因素。无法确定区分缓解与复发的预测因素。70例在基线时未诊断为MFP的受试者中有30例出现了新的MFP。高基线躯体化评分(无疼痛项目)是MFP发病的重要危险因素。
根据RDC/TMD分类的肌肉疾病主要是慢性或波动性疼痛疾病,缓解概率适中(31%)。