Kuralay Erkan, Demirkilic Ufuk, Ozal Ertugrul, Oz Bilgehan Savas, Cingöz Faruk, Günay Celalettin, Ceylan Süleyman, Arslan Mehmet, Tatar Harun
Departments of Cardiovascular Surgery, Gülhane Military Medical Academy.
J Card Surg. 2003 Mar-Apr;18(2):173-80. doi: 10.1046/j.1540-8191.2003.02025.x.
Former studies have pointed out that hemodynamic stress imposed by associated valvular disease is the primary factor in the development of ascending aorta dilatation. At present, intrinsic wall pathology is blamed for dilatation and aneurysm formation in bicuspid aortic valve (BAV).
Aortic valve replacement (AVR) was performed on 78 adult patients with BAV. Patients were divided into two groups. Group I (n = 27) underwent only AVR. Group II (n = 51) underwent AVR and additional ascending aorta procedures such as Shawl-Lapel aortoplasty (n = 12) and tailoring aortoplasty (n = 9). Dacron wrapping was performed after both techniques were done. Ascending aorta replacement was done on 11 patients by using composite graft. Supracoronary graft replacement was performed in 3 patients after AVR.
Ascending aorta diameter increment was 1.25 mm/year in normotensive and 2.80 mm/ year in hypertensive patients. Ascending aorta aneurysm (diameter > 55 mm) developed in eight patients in the postoperative period in group I. Ascending aorta dilatation did not develop in group II patients. Mean survival time +/- standard error (SE) was 128 +/- 11 and 99 +/- 4 months and survival possibility was 77.78% and 92.16%. Freedom from reoperation was 65.4% and 95.9% in 8 years in group I and group II, respectively.
Aortic wrapping with or without aortoplasty has a beneficial effect not only in dilated ascending aorta but also in all nondilated BAV patients with normal-sized aortic diameter. Ascending aorta wrapping in BAV patients preserves the endothelial lining and prevents further dilatation, aneurysm formation, and dissection.
既往研究指出,相关瓣膜疾病施加的血流动力学应激是升主动脉扩张发展的主要因素。目前,双叶主动脉瓣(BAV)的扩张和动脉瘤形成归咎于内在的管壁病变。
对78例成年BAV患者进行主动脉瓣置换术(AVR)。患者分为两组。第一组(n = 27)仅接受AVR。第二组(n = 51)接受AVR及额外的升主动脉手术,如围巾-翻领主动脉成形术(n = 12)和剪裁主动脉成形术(n = 9)。两种技术完成后均进行涤纶包裹。11例患者使用复合移植物进行升主动脉置换。3例患者在AVR后进行冠状动脉上移植物置换。
血压正常患者的升主动脉直径每年增加1.25 mm,高血压患者为每年2.80 mm。第一组8例患者在术后出现升主动脉瘤(直径> 55 mm)。第二组患者未出现升主动脉扩张。平均生存时间±标准误(SE)分别为128±11个月和99±4个月,生存可能性分别为77.78%和92.16%。第一组和第二组在8年时的再次手术率分别为65.4%和95.9%。
无论有无主动脉成形术的主动脉包裹不仅对扩张的升主动脉有益,而且对所有主动脉直径正常的非扩张BAV患者也有益。BAV患者的升主动脉包裹可保留内皮衬里,防止进一步扩张、动脉瘤形成和夹层分离。