Natsuaki M, Itoh T, Rikitake K, Okazaki Y, Naitoh K
Department of Thoracic and Cardiovascular Surgery, Saga Medical School, Japan.
J Heart Valve Dis. 1998 Sep;7(5):504-9.
Postoperative aortic complications of aortic dissection or enlargement of the ascending aortic develop in patients with aortic valve replacement (AVR) and dilated ascending aorta. This clinical study aimed to demonstrate the incidence of aortic complications after AVR in patients with dilated ascending aorta, and to clarify the surgical indication and approach for dilated ascending aorta and aortic regurgitation.
A total of 82 patients who underwent AVR between 1985 and 1997 were allocated to two groups according to the preoperative diameter of the ascending aorta. A dilated ascending aorta with diameter > or = 40 mm was seen in 38 patients (group I), and a small ascending aorta with diameter < 39 mm in 44 patients (group II). Group I patients were further allocated to two subgroups: 12 patients underwent aortoplasty (group IA) and 26 did not (group IB). Event-free rates of aortic complications and survival rate were compared between groups I and II.
Postoperative aortic dissection during the follow up period occurred in four hypertensive patients in group I (one in group IA, three in group IB); no aortic dissection was seen in group II. Freedom from all aortic complications at 10 years after surgery was 75 +/- 10% in group I and 100% in group II (p < 0.05). The cumulative survival rate at 10 years was 59 +/- 11% in group I (group IA: 71 +/- 18%, group IB: 51 +/- 14%) and 95 +/- 4% in group II (p < 0.05).
Patients with a dilated ascending aorta (> or = 40 mm diameter) were more likely to encounter complications of the aortic dissection or enlargement after AVR than those with a small ascending aorta. Surgery to prevent aortic dissection or enlargement must be selected in patients with mildly dilated ascending aorta and hypertension.
在接受主动脉瓣置换术(AVR)且升主动脉扩张的患者中,会出现主动脉夹层或升主动脉扩大的术后主动脉并发症。本临床研究旨在证明升主动脉扩张患者AVR术后主动脉并发症的发生率,并阐明升主动脉扩张和主动脉反流的手术指征及手术方法。
将1985年至1997年间接受AVR的82例患者根据术前升主动脉直径分为两组。38例患者升主动脉直径≥40mm(I组),44例患者升主动脉直径<39mm(II组)。I组患者进一步分为两个亚组:12例患者接受主动脉成形术(IA组),26例未接受(IB组)。比较I组和II组主动脉并发症无事件发生率和生存率。
随访期间,I组4例高血压患者发生术后主动脉夹层(IA组1例,IB组3例);II组未见主动脉夹层。I组术后10年无所有主动脉并发症的比例为75±10%,II组为100%(p<0.05)。I组10年累积生存率为59±11%(IA组:71±18%,IB组:51±14%),II组为95±4%(p<0.05)。
升主动脉扩张(直径≥40mm)的患者比升主动脉较小的患者在AVR术后更易发生主动脉夹层或扩大并发症。对于升主动脉轻度扩张且患有高血压的患者,必须选择预防主动脉夹层或扩大的手术。