Balon Norbert, Dupenloup Lydie, Blanc François, Weiss Michel, Rostain Jean-Claude
Université de la Méditerranée, E.A. 3280, Laboratoire de Physiopathologie et Action Thérapeutique des Gaz sous Pression, Faculté de Médecine Nord, IFR Jean Roche, 13916 Marseilles Cedex 20, France.
Neurosci Lett. 2003 Jun 5;343(2):147-9. doi: 10.1016/s0304-3940(03)00340-9.
Bilateral administration of NMDA (5 x 10(-10) mol) in the substantia nigra pars compacta increases the striatal dopamine (DA) release. However, this enhancing effect of NMDA was suppressed by nitrous oxide exposure at 0.1 MPa, which induced per se a decrease of the DA release. These results show that nitrous oxide exerts a reversal effect on the increase in striatal DA release produced by NMDA receptor activation in the substantia nigra pars compacta. This observation may be related to the fact that nitrous oxide is thought to produce its effects by acting as an NMDA receptor antagonist.
在黑质致密部双侧给予N-甲基-D-天冬氨酸（NMDA，5×10⁻¹⁰摩尔）可增加纹状体多巴胺（DA）释放。然而，在0.1兆帕压力下暴露于一氧化二氮会抑制NMDA的这种增强作用，一氧化二氮本身会导致DA释放减少。这些结果表明，一氧化二氮对黑质致密部NMDA受体激活所产生的纹状体DA释放增加具有逆转作用。这一观察结果可能与以下事实有关：一氧化二氮被认为通过作为NMDA受体拮抗剂来发挥其作用。
