Blandamura Stella, Marioni Gino, de Filippis Cosimo, Giacomelli Luciano, Segato Paola, Staffieri Alberto
Department of Pathology, Head and Neck Surgery, University of Padua, Padua, Italy.
Arch Otolaryngol Head Neck Surg. 2003 May;129(5):553-6. doi: 10.1001/archotol.129.5.553.
Inverted papilloma involving the temporal bone is an extremely rare occurrence. Reports in the literature suggest a higher recurrence rate and association with squamous cell carcinoma in Schneiderian-type papillomas of the middle ear than in sinonasal Schneiderian-type papillomas.
To investigate the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors in temporal bone inverted papillomas and to compare this entity with sinonasal papillomas. Design and Subjects We investigated 2 rare cases of inverted papilloma of the temporal bone and a control group of 6 cases of sinonasal inverted papilloma. The expression of p53, Mib-1, p27, and progesterone and estrogen receptors was determined.
In the 2 cases of temporal bone inverted papilloma, p53 expression was 43.75% and 4.92%; p27 expression was higher in temporal bone inverted papilloma (82.45% and 70.53%) than in the sinonasal inverted papilloma group. One of our 2 cases of temporal bone Schneiderian-type papilloma was positive for progesterone receptor.
The expression of progesterone receptor in 1 of our 2 cases and in the only other case reported in the literature may imply some degree of hormonal dependence of temporal bone inverted papilloma. Our analysis of the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors does not allow us to demonstrate that temporal bone and sinonasal inverted papilloma are different pathological entities.
累及颞骨的内翻性乳头状瘤极为罕见。文献报道显示，中耳施耐德型乳头状瘤的复发率高于鼻窦施耐德型乳头状瘤，且与鳞状细胞癌的关联更为密切。
研究颞骨内翻性乳头状瘤中凋亡相关蛋白、细胞增殖活性标志物及性激素受体的表达情况，并将其与鼻窦乳头状瘤进行比较。设计与研究对象我们调查了2例罕见的颞骨内翻性乳头状瘤病例，并以6例鼻窦内翻性乳头状瘤病例作为对照组。测定了p53、Mib-1、p27以及孕激素和雌激素受体的表达。
在2例颞骨内翻性乳头状瘤病例中，p53表达分别为43.75%和4.92%；颞骨内翻性乳头状瘤中p27表达（82.45%和70.53%）高于鼻窦内翻性乳头状瘤组。我们的2例颞骨施耐德型乳头状瘤病例中有1例孕激素受体呈阳性。
我们的2例病例中有1例以及文献中报道的另一例病例中孕激素受体的表达可能意味着颞骨内翻性乳头状瘤存在一定程度的激素依赖性。我们对凋亡相关蛋白、细胞增殖活性标志物及性激素受体表达的分析未能证实颞骨和鼻窦内翻性乳头状瘤是不同的病理实体。
