van der Putten Lisa, Bloemena Elisabeth, Merkus Paul, Hensen Erik F
Department of Otorhinolaryngology, Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
BMJ Case Rep. 2013 Dec 5;2013:bcr2013201219. doi: 10.1136/bcr-2013-201219.
Temporal bone Schneiderian papilloma may present as a primary tumour originating from the middle ear and mastoid process, or an extension from sinonasal disease. Both forms are rare, this being only the 18th case of primary temporal bone Schneiderian papilloma described to date. Although the current patient has remained disease free after excision of the papilloma, the reported recurrence rate is high, comparable to sinonasal Schneiderian papilloma with extrasinus extension. Malignant progression of primary Schneiderian papillomas is significantly reduced as compared to Schneiderian papillomas that extend from the sinonasal tract into the temporal bone. A positive human papilloma virus status, as found in this case, is a common feature and prognostic factor of sinonasal Schneiderian papilloma but an infrequent finding in temporal bone disease. Owing to the high recurrence rate, the risk of malignant progression and the absence of reliable prognostic markers, stringent follow-up consisting of otoscopy, nasendoscopy and imaging is essential.
颞骨内翻性乳头状瘤可表现为起源于中耳和乳突的原发性肿瘤，或为鼻窦疾病的蔓延。这两种形式都很罕见，这是迄今为止报道的第18例原发性颞骨内翻性乳头状瘤。尽管目前该患者在切除乳头状瘤后无疾病复发，但据报道其复发率很高，与伴有鼻窦外蔓延的鼻窦内翻性乳头状瘤相当。与从鼻窦延伸至颞骨的内翻性乳头状瘤相比，原发性内翻性乳头状瘤的恶性进展明显减少。如本病例中发现的人乳头瘤病毒阳性状态，是鼻窦内翻性乳头状瘤的常见特征和预后因素，但在颞骨疾病中并不常见。由于复发率高、恶性进展风险以及缺乏可靠的预后标志物，因此通过耳镜检查、鼻内镜检查和影像学检查进行严格随访至关重要。
