Okawa Toru, Konno Akiyoshi, Yamakoshi Takayuki, Numata Tsutomu, Terada Nobuhisa, Shima Masayuki
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Int Arch Allergy Immunol. 2003 May;131(1):39-45. doi: 10.1159/000070433.
The marked increase in the incidence of Japanese cedar (Cryptomeria japonica; JC) pollinosis is a social problem in Japan. Elucidation of its natural history is, therefore, essential.
Cross-sectional and vertical-sectional studies were performed regarding the effects of aging on sensitization to Japanese cedar pollen (JCP) and development of JC pollinosis by measuring serum IgE titers to JCP and by oral examination of residents of the Maruyama Town, Chiba, Japan from 1995 to 2001. We also studied the incidence of its spontaneous remission and the background factors.
In a vertical-sectional study, the serum IgE titer to JCP was strongly influenced by the amounts of pollen scattered. An increase in age by 6 years did not reduce the IgE titer to JCP in subjects in their 40s. However, in subjects aged 60 or more, annual differences in the JCP count did not affect serum IgE titer to JCP, which remained low even after a season with a high pollen count. In subjects with JC pollinosis aged over 40 showing a CAP RAST score of more than 2 to JCP in 1995, spontaneous remission of JC pollinosis was observed in 16.1% over a period of 6 years. Factors affecting spontaneous remission include sex, age at the time, serum IgE titer to JCP and age at first onset of JC pollinosis.
The CAP RAST score was strongly associated with spontaneous remission in the multivariable model.
日本柳杉花粉症发病率显著上升是日本的一个社会问题。因此，阐明其自然病史至关重要。
通过测量对日本柳杉花粉（JCP）的血清IgE滴度，并对1995年至2001年期间日本千叶县丸山町居民进行口腔检查，开展了关于衰老对日本柳杉花粉致敏及日本柳杉花粉症发展影响的横断面和纵断面研究。我们还研究了其自发缓解的发生率及背景因素。
在纵断面研究中，对JCP的血清IgE滴度受花粉散落量的强烈影响。40多岁的受试者年龄增加6岁并不会降低对JCP的IgE滴度。然而，在60岁及以上的受试者中，JCP计数的年度差异并未影响对JCP的血清IgE滴度，即使在花粉计数高的季节后该滴度仍保持较低水平。在1995年对JCP的CAP RAST评分超过2分的40岁以上日本柳杉花粉症患者中，6年内观察到16.1%的患者日本柳杉花粉症自发缓解。影响自发缓解的因素包括性别、当时的年龄、对JCP的血清IgE滴度以及日本柳杉花粉症首次发病时的年龄。
在多变量模型中，CAP RAST评分与自发缓解密切相关。
