Kanazawa Atsuko, Terada Tetsuya, Ozasa Kotaro, Hyo Sawako, Araki Natsuko, Kawata Ryo, Takenaka Hiroshi
Department of Otorhinolaryngology, Osaka Medical College, Osaka, Japan.
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Allergol Int. 2014 Mar;63(1):95-101. doi: 10.2332/allergolint.13-OA-0592.
Intra individual longitudinal data has been lacking for IgE-mediated seasonal allergic rhinitis (SAR), especially in young children. Little is known about the development and natural course of SAR in terms of prevalence and incidence rates in schoolchildren.
In May or June each year from 1994 to 2007, schoolchildren were assessed for serum Japanese cedar pollen (JCP)-IgE and house dust mite (HDM)-IgE levels, and surveyed regarding nasal symptoms.
Among the 220 children initially assessed in the first grade, 69 (31.4%) were already sensitized to JCP at first grade and 119 (54.1%) did not develop JCP sensitivity during the 6-year study at all. In the first grade children who were HDM-sensitized but JCP non-sensitized, JCP-IgE level was significantly elevated compared to the JCP and HDM non-sensitized group. This seems to indicate that HDM sensitization was very strongly associated with JCP sensitization.
Elevated serum IgE is a consequence of specific sensitization to HDM and HDM sensitization appeared to develop prior to the start of primary school which distinguishes HDM sensitization from JCP sensitization.
关于IgE介导的季节性变应性鼻炎（SAR），尤其是幼儿的个体内纵向数据一直缺乏。关于学龄儿童中SAR的患病率和发病率方面的发展及自然病程知之甚少。
在1994年至2007年每年的5月或6月，对学龄儿童进行血清日本柳杉花粉（JCP）-IgE和屋尘螨（HDM）-IgE水平评估，并就鼻部症状进行调查。
在最初一年级接受评估的220名儿童中，69名（31.4%）在一年级时已对JCP致敏，119名（54.1%）在6年研究期间根本未发生JCP敏感性。在对HDM致敏但对JCP未致敏的一年级儿童中，与对JCP和HDM均未致敏的组相比，JCP-IgE水平显著升高。这似乎表明HDM致敏与JCP致敏密切相关。
血清IgE升高是对HDM特异性致敏的结果，且HDM致敏似乎在小学入学前就已发生，这将HDM致敏与JCP致敏区分开来。
