Simon Michael R, Reher Randall L, Long P Michael, Yellayi Kalyani
Division of Pulmonary and Critical Care Medicine, Allergy and Immunology, Henry Ford Health System, Detroit, Mich., USA.
Int Arch Allergy Immunol. 2003 May;131(1):53-6. doi: 10.1159/000070435.
High osmolal ionic radiocontrast media (RCM) cause vascular release of endothelin-1 (ET-1) and activate mast cells. Iomeprol, a nonionic RCM, has recently been reported not to activate cardiac mast cells. This coronary angiography study was performed to extend those findings using another nonionic RCM, iopromide, and to further determine whether iopromide causes release of ET-1.
Pulmonary artery plasma ET-1, histamine and serum tryptase were determined before and 30 min following angiography with iopromide in 11 subjects. ET-1, histamine and tryptase were measured using immunoassays.
The concentrations of ET-1 (1.36 +/- 0.66 pg/ml), histamine (2.63 +/- 1.15 nM), and beta (<1 microg/l) as well as total tryptase (8.25 +/- 4.63 microg/l) in the preangiography samples were within the normal range. Following angiography, the concentrations of ET-1 (0.95 +/- 0.80 pg/ml), histamine (3.08 +/- 1.06 nM), and beta (<1 microg/l) and total tryptase (7.00 +/- 5.56 microg/l) were not significantly different. None of the subjects demonstrated a postangiography increase in mediator concentration.
This study demonstrates the lack of release of ET-1 by iopromide. The lack of cardiac mast cell activation by iopromide is consistent with the report that iomeprol also does not activate cardiac mast cells.
高渗离子型放射造影剂（RCM）可导致血管内皮素-1（ET-1）释放并激活肥大细胞。碘海醇，一种非离子型RCM，最近有报道称其不会激活心脏肥大细胞。本冠状动脉造影研究旨在使用另一种非离子型RCM碘普罗胺扩展这些发现，并进一步确定碘普罗胺是否会导致ET-1释放。
在11名受试者中，于使用碘普罗胺进行血管造影前及造影后30分钟测定肺动脉血浆ET-1、组胺和血清类胰蛋白酶。使用免疫测定法测量ET-1、组胺和类胰蛋白酶。
血管造影前样本中ET-1（1.36±0.66 pg/ml）、组胺（2.63±1.15 nM）、β（<1 μg/l）以及总类胰蛋白酶（8.25±4.63 μg/l）的浓度均在正常范围内。血管造影后，ET-1（0.95±0.80 pg/ml）、组胺（3.08±1.06 nM）、β（<1 μg/l）和总类胰蛋白酶（7.00±5.56 μg/l）的浓度无显著差异。所有受试者造影后介质浓度均未升高。
本研究表明碘普罗胺不会导致ET-1释放。碘普罗胺不会激活心脏肥大细胞这一结果与碘海醇也不会激活心脏肥大细胞的报道一致。
