Sheahan Patrick, Fitzgibbon Jim, Lee Gary, O'Leary Gerard
Department of Otolaryngology, South Infirmary Victoria Hospital, Cork, Ireland.
Eur Arch Otorhinolaryngol. 2003 Oct;260(9):509-12. doi: 10.1007/s00405-003-0616-9. Epub 2003 May 21.
Adenosquamous carcinoma is a very rare tumor that is characterized pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Only 15 cases in the oral cavity are reported in the literature, most occurring in middle-aged and elderly males. Pain is a commonly reported presenting symptom and may be related to the frequent presence of perineural invasion. Most cases have been treated surgically. However, early recurrence and death due to disease are common. We report an exceptional case occurring in a 22-year-old female. The tumor was associated with dysplasia of both minor salivary gland ductal epithelium and surface mucosal epithelium. Perineural invasion was also present. The patient was treated with combined surgery and radiotherapy and remained well for 9 months before developing locoregional recurrence and ultimately succumbing to the disease.
腺鳞癌是一种非常罕见的肿瘤，其病理特征是同时存在腺癌和鳞状细胞癌的不同区域。文献中仅报道了15例口腔腺鳞癌，大多数发生在中老年男性。疼痛是常见的首发症状，可能与神经周围侵犯的频繁发生有关。大多数病例采用手术治疗。然而，疾病早期复发和死亡很常见。我们报告了一例发生在一名22岁女性的特殊病例。该肿瘤与小涎腺导管上皮和表面黏膜上皮发育异常有关。也存在神经周围侵犯。患者接受了手术和放疗联合治疗，在局部区域复发并最终死于该疾病之前，病情稳定了9个月。
