Abdelsayed R A, Sangueza O P, Newhouse R F, Singh B S
Oral and Maxillofacial Pathology Department, School of Dentistry, Medical College of Georgia, Augusta 30912-1110, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Feb;85(2):173-7. doi: 10.1016/s1079-2104(98)90422-x.
The histogenetic origin of adenosquamous carcinoma, a high-grade variant of malignant epithelial neoplasm, has long been debated. We report a case that clearly demonstrated a mucosal surface epithelial origin. This concept was supported through histologic analysis of hematoxylin- and eosin-stained sections, as well as by the pattern of immunohistochemical reactivity with antibodies directed against low and high molecular weight cytokeratins, cell adhesion molecules (CAM 5.2), and carcinoembryonic antigens. The histologic differential diagnosis, biological behavior, and prognosis of adenosquamous carcinoma are also examined.
腺鳞癌是一种恶性上皮性肿瘤的高级别变体，其组织发生学起源长期以来一直存在争议。我们报告了一例明确显示为黏膜表面上皮起源的病例。通过苏木精和伊红染色切片的组织学分析，以及针对低分子量和高分子量细胞角蛋白、细胞黏附分子（CAM 5.2）和癌胚抗原的抗体的免疫组化反应模式，这一概念得到了支持。本文还探讨了腺鳞癌的组织学鉴别诊断、生物学行为及预后。
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