A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2.
作者信息
Sommer Alexandra, Rickert Rainer, Fischer Peter, Steinhart Hans, Walter Rolf D, Liebau Eva
机构信息
Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
出版信息
Infect Immun. 2003 Jun;71(6):3603-6. doi: 10.1128/IAI.71.6.3603-3606.2003.
Abstract
The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D(2) directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.
摘要
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