Doctor K S, Reed J C, Godzik A, Bourne P E
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell Death Differ. 2003 Jun;10(6):621-33. doi: 10.1038/sj.cdd.4401230.
The apoptosis database is a public resource for researchers and students interested in the molecular biology of apoptosis. The resource provides functional annotation, literature references, diagrams/images, and alternative nomenclatures on a set of proteins having 'apoptotic domains'. These are the distinctive domains that are often, if not exclusively, found in proteins involved in apoptosis. The initial choice of proteins to be included is defined by apoptosis experts and bioinformatics tools. Users can browse through the web accessible lists of domains, proteins containing these domains and their associated homologs. The database can also be searched by sequence homology using basic local alignment search tool, text word matches of the annotation, and identifiers for specific records. The resource is available at http://www.apoptosis-db.org and is updated on a regular basis.
凋亡数据库是一个供对凋亡分子生物学感兴趣的研究人员和学生使用的公共资源。该资源提供了关于一组具有“凋亡结构域”的蛋白质的功能注释、文献参考、图表/图像以及替代命名法。这些是通常（如果不是唯一的话）在参与凋亡的蛋白质中发现的独特结构域。要纳入的蛋白质的初始选择由凋亡专家和生物信息学工具确定。用户可以浏览可通过网络访问的结构域列表、包含这些结构域的蛋白质及其相关同源物。该数据库还可以使用基本局部比对搜索工具通过序列同源性、注释的文本单词匹配以及特定记录的标识符进行搜索。该资源可在http://www.apoptosis-db.org获取，并定期更新。
