Jato-Rodriguez J J, Nelson J D, Mookerjea S
Biochim Biophys Acta. 1976 May 28;428(3):639-46. doi: 10.1016/0304-4165(76)90193-8.
Rat endometrium was found to contain a UDPgalactose pyrophosphatase for the hydrolysis of UDPgalactose into galactose 1-phosphate and UMP. The adminstration of 17beta-estradiol to ovariectomized rats resulted in a significant decrease in the activity of the enzyme in endometrium while have little effect on that in myometrium. The response was linear with the dose of estradiol and as little as 0.07 mug per 100 g body weight produced maximum inhibition of the enzyme. Progesterone on its own had little effect on the enzyme activity but in combination with estradiol, it effectively prevented the inhibitory effect of estradiol. This inhibitory effect of estradiol on the activity of UDPgalactose pyrophosphatase may function in the regulation of glycoprotein biosynthesis in endometrium.
研究发现，大鼠子宫内膜含有一种UDP-半乳糖焦磷酸酶，可将UDP-半乳糖水解为1-磷酸半乳糖和UMP。给去卵巢大鼠注射17β-雌二醇后，子宫内膜中该酶的活性显著降低，而对子宫肌层中该酶的活性影响不大。这种反应与雌二醇的剂量呈线性关系，每100克体重低至0.07微克就能产生最大程度的酶抑制作用。孕酮本身对酶活性影响不大，但与雌二醇联合使用时，能有效阻止雌二醇的抑制作用。雌二醇对UDP-半乳糖焦磷酸酶活性的这种抑制作用可能在子宫内膜糖蛋白生物合成的调节中发挥作用。
