再生大鼠肝脏中糖基化能力的增强与CMP-N-乙酰神经氨酸水解酶和UDP-半乳糖焦磷酸酶活性的降低同时出现。
Increased glycosylation capacity in regenerating rat liver is paralleled by decreased activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase.
作者信息
Van Dijk W, Lasthuis A M, Trippelvitz L A, Muilerman H G
出版信息
Biochem J. 1983 Sep 15;214(3):1003-6. doi: 10.1042/bj2141003.
Abstract
In regenerating rat liver the activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase were decreased to 40-50% of control values within 35 h after partial hepatectomy. In the same time period the activities of sialyltransferase and galactosyltransferase were increased, and the initial sharp decrease in the carbohydrate content of liver and serum glycoproteins was largely restored. The antiparallel nature of these events is suggestive of an involvement of nucleotide-sugar-hydrolysis enzymes in rat liver glycoprotein biosynthesis.
摘要
在再生的大鼠肝脏中，部分肝切除术后35小时内，CMP-N-乙酰神经氨酸水解酶和UDP-半乳糖焦磷酸酶的活性降至对照值的40 - 50%。在同一时期，唾液酸转移酶和半乳糖基转移酶的活性增加，肝脏和血清糖蛋白碳水化合物含量最初的急剧下降在很大程度上得到恢复。这些事件的反平行性质提示核苷酸糖水解酶参与了大鼠肝脏糖蛋白的生物合成。
相似文献
1
Increased glycosylation capacity in regenerating rat liver is paralleled by decreased activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase.再生大鼠肝脏中糖基化能力的增强与CMP-N-乙酰神经氨酸水解酶和UDP-半乳糖焦磷酸酶活性的降低同时出现。
Biochem J. 1983 Sep 15;214(3):1003-6. doi: 10.1042/bj2141003.
2
Galactose metabolism in regenerating rat liver.再生大鼠肝脏中的半乳糖代谢
Biochem J. 1976 Jan 15;154(1):141-7. doi: 10.1042/bj1540141.
3
Effect of uridine on hepatic galactose-1-phosphate uridyltransferase.尿苷对肝脏1-磷酸半乳糖尿苷酰转移酶的作用。
Enzyme. 1989;42(1):53-60. doi: 10.1159/000469007.
4
Changing activities of galactose-metabolizing enzymes during perfusion of suckling-rat liver.乳鼠肝脏灌注过程中半乳糖代谢酶活性的变化
Am J Physiol. 1981 Mar;240(3):E333-9. doi: 10.1152/ajpendo.1981.240.3.E333.
5
On the presence of two non-specific nucleotide-sugar-hydrolysing enzymes in rat liver.大鼠肝脏中两种非特异性核苷酸糖水解酶的存在
Biochem J. 1984 May 15;220(1):95-103. doi: 10.1042/bj2200095.
6
Activity of hepatic galactose-metabolizing enzymes in the pregnant rat and fetus.妊娠大鼠和胎儿肝脏中半乳糖代谢酶的活性
Pediatr Res. 1989 Feb;25(2):161-6. doi: 10.1203/00006450-198902000-00017.
7
Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum.两歧双歧杆菌中UDP-葡萄糖（UDP-半乳糖）焦磷酸化酶的纯化及性质
J Biochem. 1979 Oct;86(4):923-8. doi: 10.1093/oxfordjournals.jbchem.a132624.
8
Developmental aspects of galactose-1-phosphate uridylytransferase in rat intestine.大鼠肠道中1-磷酸半乳糖尿苷酰转移酶的发育情况
Biol Neonate. 1975;27(3-4):153-62. doi: 10.1159/000240772.
9
Galactose as a regulatory factor of its own metabolism by rat liver.半乳糖作为大鼠肝脏自身代谢的调节因子。
Metabolism. 1989 Aug;38(8):810-5. doi: 10.1016/0026-0495(89)90072-3.
10
The occurrence of the Leloir pathway in non-pathogenic mycobacteria.非致病性分枝杆菌中Leloir途径的存在。
Acta Microbiol Pol. 1981;30(4):327-33.
引用本文的文献
1
Engineering of sialylated mucin-type O-glycosylation in plants.在植物中工程化唾液酸化粘蛋白型 O-糖基化。
J Biol Chem. 2012 Oct 19;287(43):36518-26. doi: 10.1074/jbc.M112.402685. Epub 2012 Sep 4.
2
Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose.一种能切割UDP-葡萄糖焦磷酸键的哺乳动物类Nudix水解酶的克隆、表达及特性分析
Biochem J. 2003 Mar 1;370(Pt 2):409-15. doi: 10.1042/BJ20021140.
3
On the presence of two non-specific nucleotide-sugar-hydrolysing enzymes in rat liver.大鼠肝脏中两种非特异性核苷酸糖水解酶的存在
Biochem J. 1984 May 15;220(1):95-103. doi: 10.1042/bj2200095.
4
The metabolism of sialic acids in isolated rat colonic mucosal cells.大鼠离体结肠黏膜细胞中唾液酸的代谢
Biochem J. 1985 Feb 15;226(1):163-74. doi: 10.1042/bj2260163.
5
Postnatal changes in sialylation of glycoproteins in rat liver.大鼠肝脏中糖蛋白唾液酸化的产后变化
Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):179-85. doi: 10.1042/bj2800179.
本文引用的文献
1
Metabolism of sialic acid in regenerating rat liver.再生大鼠肝脏中唾液酸的代谢
Biochem J. 1980 Jun 15;188(3):905-11. doi: 10.1042/bj1880905.
2
Turnover of free sialic acid, CMP-sialic acid, and bound sialic acid in rat brain.大鼠脑中游离唾液酸、CMP-唾液酸和结合唾液酸的周转
J Neurochem. 1981 Apr;36(4):1492-9. doi: 10.1111/j.1471-4159.1981.tb00591.x.
3
Alkaline phosphodiesterase-active antigens in plasma membranes of rat liver.大鼠肝细胞膜中的碱性磷酸二酯酶活性抗原
Biochim Biophys Acta. 1980 May 23;598(2):305-13. doi: 10.1016/0005-2736(80)90008-5.
4
A universal and rapid spectrophotometric assay of CMP-sialic acid hydrolase and nucleoside-diphosphosugar pyrophosphatase activities and detection in polyacrylamide gels.一种用于检测CMP-唾液酸水解酶和核苷二磷酸糖焦磷酸酶活性的通用快速分光光度法及其在聚丙烯酰胺凝胶中的检测。
Anal Biochem. 1981 Nov 1;117(2):346-53. doi: 10.1016/0003-2697(81)90791-0.
5
Subcellular and regional distribution of CMP-N-acetylneuraminic acid synthetase in the calf kidney.小牛肾中CMP-N-乙酰神经氨酸合成酶的亚细胞和区域分布
Biochim Biophys Acta. 1973 Jul 5;315(1):162-75. doi: 10.1016/0005-2744(73)90139-3.
6
Biosynthesis of N-acetylneuraminic acid in Morris hepatomas.N-乙酰神经氨酸在莫里斯肝癌中的生物合成。
Eur J Biochem. 1973 Jan 15;32(2):254-62. doi: 10.1111/j.1432-1033.1973.tb02605.x.
7
Effect of estradiol and progesterone on UDPgalactose pyrophosphatase activity in the endometrium of ovariectomized rats.雌二醇和孕酮对去卵巢大鼠子宫内膜中UDP半乳糖焦磷酸酶活性的影响。
Biochim Biophys Acta. 1976 May 28;428(3):639-46. doi: 10.1016/0304-4165(76)90193-8.
8
Galactose metabolism in regenerating rat liver.再生大鼠肝脏中的半乳糖代谢
Biochem J. 1976 Jan 15;154(1):141-7. doi: 10.1042/bj1540141.
9
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
10
Synthesis in vitro of glycoprotein in regenerating rat liver.再生大鼠肝脏中糖蛋白的体外合成
Biochim Biophys Acta. 1977 Jul 21;498(1):272-81. doi: 10.1016/0304-4165(77)90265-3.
Zotero 插件