再生大鼠肝脏中糖基化能力的增强与CMP-N-乙酰神经氨酸水解酶和UDP-半乳糖焦磷酸酶活性的降低同时出现。
Increased glycosylation capacity in regenerating rat liver is paralleled by decreased activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase.
作者信息
Van Dijk W, Lasthuis A M, Trippelvitz L A, Muilerman H G
出版信息
Biochem J. 1983 Sep 15;214(3):1003-6. doi: 10.1042/bj2141003.
Abstract
In regenerating rat liver the activities of CMP-N-acetylneuraminate hydrolase and UDP-galactose pyrophosphatase were decreased to 40-50% of control values within 35 h after partial hepatectomy. In the same time period the activities of sialyltransferase and galactosyltransferase were increased, and the initial sharp decrease in the carbohydrate content of liver and serum glycoproteins was largely restored. The antiparallel nature of these events is suggestive of an involvement of nucleotide-sugar-hydrolysis enzymes in rat liver glycoprotein biosynthesis.
摘要
在再生的大鼠肝脏中，部分肝切除术后35小时内，CMP-N-乙酰神经氨酸水解酶和UDP-半乳糖焦磷酸酶的活性降至对照值的40 - 50%。在同一时期，唾液酸转移酶和半乳糖基转移酶的活性增加，肝脏和血清糖蛋白碳水化合物含量最初的急剧下降在很大程度上得到恢复。这些事件的反平行性质提示核苷酸糖水解酶参与了大鼠肝脏糖蛋白的生物合成。
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本文引用的文献
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