[实验性变应性鼻炎鼻黏膜中神经生长因子的测定]
[Measurement of nerve growth factor in the nasal mucosa of experimental allergic rhinitis].
作者信息
Zhao S, Zhou X
机构信息
Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Aug;36(4):275-7.
OBJECTIVE
To investigate the role of nerve growth factor in the development of allergic rhinitis.
METHODS
Animal model of allergic rhinitis was established in rat, the content of nerve growth factor in the nasal mucosa was measured using enzyme-linked immunosorbent assay (ELISA) technique.
RESULTS
The content of nerve growth factor significantly (P < 0.001) increased in the nasal mucosa of experimental allergic rhinitis (6.65 +/- 0.42) ng/g wet weight, compared with that in control animals (3.51 +/- 0.29) ng/g wet weight.
CONCLUSION
Nerve growth factor may play an important role in the development of allergic rhinitis by regulating expression and release of neuropeptides and/or by activating immune cells such as mast cells.
目的
探讨神经生长因子在变应性鼻炎发病中的作用。
方法
建立大鼠变应性鼻炎动物模型，采用酶联免疫吸附测定（ELISA）技术检测鼻黏膜中神经生长因子的含量。
结果
实验性变应性鼻炎大鼠鼻黏膜中神经生长因子含量显著升高（P < 0.001），为（6.65 ± 0.42）ng/g湿重，而对照动物为（3.51 ± 0.29）ng/g湿重。
结论
神经生长因子可能通过调节神经肽的表达和释放和/或激活肥大细胞等免疫细胞，在变应性鼻炎发病中起重要作用。
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