[变应性鼻炎大鼠模型鼻黏膜中转化生长因子β1和碱性成纤维细胞生长因子-2的动态表达]
[The dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa in the allergic rhinitis rat models].
作者信息
Xie Bingbin, Liu Yuehui, Luo Gui, Liu Jianguo, Zhong Yanping, Mei Xiaofeng
机构信息
Department of Otorhinolaryngology, Foshan Hospital of Traditional Medicine, Foshan, 528000, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jul;24(14):655-8.
OBJECTIVE
To investigate the dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rat models of allergic rhinitis, at different stages of the process during pathogenesis.
METHOD
One hundred and eighty Sprague-Dawley (SD) rats were randomly divided into three groups, the normal Group A used for contrast and experimental groups: Group B and C, each group were 60 rats. Then, observed the expression of the TGF-beta1 and FGF-2 in the nasal mucosa at different stages of the process by immunohistochemical staining.
RESULT
The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of the normal Group A was negative, while the Group B and Group C were varying degrees of positive both, and Group B, the level of the TGF-beta1 and FGF-2 were both decline after allergen avoidance, but still more not ability than the expression of the Group B (P < 0.05).
CONCLUSION
The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rats models were varying degrees of positive , and it is decline while the allergen avoidance.
目的
研究变应性鼻炎大鼠模型鼻黏膜在发病过程不同阶段中转化生长因子β1（TGF-β1）和碱性成纤维细胞生长因子（FGF-2）的动态表达。
方法
将180只Sprague-Dawley（SD）大鼠随机分为3组，正常对照组A组用于对照，实验组B组和C组，每组60只大鼠。然后，通过免疫组织化学染色观察TGF-β1和FGF-2在发病过程不同阶段鼻黏膜中的表达。
结果
正常A组大鼠鼻黏膜中TGF-β1和FGF-2的表达为阴性，而B组和C组均为不同程度的阳性，且B组在避免变应原后TGF-β1和FGF-2水平均下降，但仍高于A组表达水平（P<0.05）。
结论
大鼠模型鼻黏膜中TGF-β1和FGF-2的表达呈不同程度阳性，且在避免变应原时下降。
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