[一氧化氮合酶诱导型同工型mRNA的表达及其在鼻息肉中的作用]
[Expression of the inducible isoform of nitric oxide synthase mRNA and the role in nasal polyps].
作者信息
Jiang S, Dong Z, Yang Z
机构信息
Department of Otolaryngology & Head and Neck Surgery, China-Japan Union Hospital, Bethune Faculty of Medicine, Jilin University, Changchun 130031, China.
出版信息
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2001 Aug;36(4):298-300.
OBJECTIVE
To explore the pathogenesis of nasal polyps. The aim of this study is to detect the expression of inducible isoform of nitric oxide synthase (iNOS) in nasal polyp tissue, and to compare these findings with that in normal nasal turbinate.
METHODS
We examined the expression of iNOS in human nasal polyps from patients undergoing nasal polypectomy (n = 8) and nasal turbinectomy(n = 6). The iNOS mRNA expression was determined by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR).
RESULTS
The iNOS mRNA expression was significantly stronger in the nasal polyps (NP) than that in turbinate tissues (P < 0.01).
CONCLUSIONS
iNOS expression is upregulated in NP, which indicate that iNOS and NO may play a potential role in the formation and growth of NP.
目的
探讨鼻息肉的发病机制。本研究旨在检测鼻息肉组织中诱导型一氧化氮合酶（iNOS）的表达，并将这些结果与正常鼻甲组织中的表达进行比较。
方法
我们检测了接受鼻息肉切除术的患者（n = 8）和鼻甲切除术的患者（n = 6）的人鼻息肉中iNOS的表达。通过半定量逆转录-聚合酶链反应（RT-PCR）测定iNOS mRNA的表达。
结果
鼻息肉（NP）中iNOS mRNA的表达明显强于鼻甲组织（P < 0.01）。
结论
NP中iNOS表达上调，这表明iNOS和NO可能在NP的形成和生长中发挥潜在作用。
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