[去神经支配后不同时期兔骨骼肌组蛋白浓度的变化]
[Changes in rabbit skeletal muscle histone concentration at different periods following denervation].
作者信息
Dambinova S A
出版信息
Biokhimiia. 1976 Feb;41(2):324-7.
Dynamics of changes in histone fractions isolated from nuclei of rabbit skeletal muscles after the denervation is investigated by means of ion-exchange chromatography on CM-cellulose and polyacrylamide gel electrophoresis. It is shown that the content of arginine-rich histone fraction F2a1 is significantly increased, and that of lysine-rich histone fraction F1 is decreased on the sixth day after the denervation. Pre-operational injections of actinomycin D prevented these changes. The early suggestion about nervous control of transcription in rabbit skeletal muscles is confirmed.
通过在CM-纤维素上进行离子交换色谱分析和聚丙烯酰胺凝胶电泳，研究了去神经支配后从兔骨骼肌细胞核中分离出的组蛋白组分的变化动态。结果表明，富含精氨酸的组蛋白组分F2a1的含量在去神经支配后第六天显著增加，而富含赖氨酸的组蛋白组分F1的含量则降低。术前注射放线菌素D可防止这些变化。关于兔骨骼肌转录的神经控制的早期推测得到了证实。
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