Hu Yuanchun, Liang Xinmiao, Wang Junwei, Zheng Zhuo, Hu Xinquan
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, People's Republic of China.
J Org Chem. 2003 May 30;68(11):4542-5. doi: 10.1021/jo0340758.
A new type of phosphite-pyridine (P,N) ligand derived from (S)-NOBIN and (S)-BINOL was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to chalcones. The new P,N ligands were highly efficient in the copper-catalyzed enantioselective 1,4-conjugate additions of diethylzinc to acyclic enones, and up to 97% ee was achieved.
一种由(S)-NOBIN和(S)-BINOL衍生而来的新型亚磷酸酯-吡啶(P,N)配体被用于铜(I)催化的二乙基锌与查耳酮的共轭加成反应中。这种新型P,N配体在铜催化的二乙基锌与开链烯酮的对映选择性1,4-共轭加成反应中表现出高效性,对映体过量值(ee)高达97%。