Wan Huihui, Hu Yuanchun, Liang Yuxue, Gao Shuang, Wang Junwei, Zheng Zhuo, Hu Xinquan
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China.
J Org Chem. 2003 Oct 17;68(21):8277-80. doi: 10.1021/jo0345897.
A new series of fine-tunable phosphite-pyridine (P,N) ligands derived from (S)-2-amino-2'-hydroxy-6,6'-dimethyl-1,1'-biphenyl and (S)-2-amino-2'-hydroxy-4,4',6,6'-tetramethyl-1,1'-biphenyl was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to acyclic enones. Excellent enantioselectivities (up to 98% ee) and highly catalytic activities were achieved for a variety of acyclic enones.
一系列由（S）-2-氨基-2'-羟基-6,6'-二甲基-1,1'-联苯和（S）-2-氨基-2'-羟基-4,4',6,6'-四甲基-1,1'-联苯衍生而来的新型可微调亚磷酸酯-吡啶（P，N）配体被用于铜（I）催化的二乙基锌与开链烯酮的共轭加成反应。对于多种开链烯酮，该反应实现了优异的对映选择性（高达98% ee）和高催化活性。
