Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Chirality. 2011 Feb;23(2):105-12. doi: 10.1002/chir.20881.
New amino acid-based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et(2) Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)-1e under mild conditions.
新型氨基酸基模块化手性配体易于合成,并在各种铜源存在下用于催化 Et(2)Zn 与各种环状烯酮的不对称共轭加成。在温和条件下,使用配体 (S)-1e 可获得高达 72%的中等 ee 值。