Tchuraev Rustem N, Galimzyanov Alexander V
Institute of Biology, Ufa Research Center, Russian Academy of Sciences, Ufa, Russia.
In Silico Biol. 2003;3(1-2):101-15. Epub 2003 Mar 30.
Using the method of generalized threshold models, the problem is formulated and solved to evaluate the parametric stability of the model of a gene subnetwork controlling the early ontogenesis of the fruit fly Drosophila melanogaster. Computer experiments have been performed to test the parametric stability of the model. Quantitative evaluations have been obtained for parametric stability of the Drosophila gene subnetwork in nuclei along the embryo's anterior-posterior axis. The results of computer experiments have been compared with the previous research data on "sensitivity" of functioning regimes to random changes of the parameters in the models of prokaryotic and eukaryotic systems, namely the system controlling the lambda-phage development and the subsystem controlling the flower morphogenesis of Arabidopsis thaliana. The obtained results confirm high parametric stability of gene networks that control the development of organisms.
利用广义阈值模型方法，对控制果蝇黑腹果蝇早期个体发育的基因子网模型的参数稳定性进行了问题的提出与求解。进行了计算机实验以测试该模型的参数稳定性。获得了果蝇基因子网在沿胚胎前后轴的细胞核中的参数稳定性的定量评估。计算机实验结果与先前关于原核和真核系统模型中功能状态对参数随机变化的“敏感性”的研究数据进行了比较，即控制λ噬菌体发育的系统和控制拟南芥花形态发生的子系统。所得结果证实了控制生物体发育的基因网络具有高参数稳定性。
