Burstein Z
Institute for Philosophy of Science, Tel-Aviv University, Israel.
J Theor Biol. 1995 May 7;174(1):1-11. doi: 10.1006/jtbi.1995.0075.
A network model of development governing the whole temporal and spatial hierarchy of early embryogenesis and pattern formation in Drosophila is introduced. The network is related to a neural network model, with its units being developmental genes mostly connected by the genes' DNA-binding products. The developmental network's agreement with predictions regarding architecture and function of the neural network provides adequate grounds for an analogy between the two. The model is tested through computer simulations--predictions compare favorably with experimental observations. The model not only incorporates a program of control at gene level, but also makes a direct connection with current molecular studies throughout the whole hierarchy of the early embryogenesis of Drosophila.
介绍了一种调控果蝇早期胚胎发生和模式形成的整个时空层次的发育网络模型。该网络与神经网络模型相关，其单元是发育基因，大多通过基因的DNA结合产物相连。发育网络在结构和功能上与神经网络预测的一致性为两者之间的类比提供了充分依据。该模型通过计算机模拟进行测试——预测结果与实验观察结果吻合良好。该模型不仅纳入了基因水平的控制程序，还在果蝇早期胚胎发生的整个层次上与当前的分子研究建立了直接联系。
