Schettini F, de Mattia D, Mautone A, Altomare M
Biol Neonate. 1976;29(1-2):82-8. doi: 10.1159/000240851.
Postnatal development of factor II molecule has been evaluated by three different methods in infants and children from 15 days to 7 years of age. The immunochemical determination of factor II showed that the plasma levels of this factor reached the lowest adult values between 4-7 months of age and rose slowly for all the first year; after this age the plasma concentration was steady. The adult range was reached from 15 to 120 days of age when the factor II was evaluated by the method of Owren and Aas (19) and by staphylocoagulase reagent.
采用三种不同方法对15天至7岁婴幼儿及儿童体内凝血因子II分子的产后发育情况进行了评估。凝血因子II的免疫化学测定结果显示，该因子的血浆水平在4至7个月龄时降至成人最低值，并在出生后的第一年缓慢上升；此后血浆浓度保持稳定。当采用奥伦和阿斯（19）的方法以及葡萄球菌凝固酶试剂评估凝血因子II时，15至120日龄时达到成人范围。
