血管内皮生长因子的表达与垂体腺瘤囊性成分及出血的相关性

The association of the expression of vascular endothelial growth factor with the cystic component and haemorrhage in pituitary adenoma.

作者信息

Fukui Shinji, Otani Naoki, Nawashiro Hiroshi, Yano Akiko, Nomura Namiko, Tokumaru Aya M, Miyazawa Takahito, Ohnuki Akira, Tsuzuki Nobusuke, Katoh Hiroshi, Ishihara Shoichiro, Shima Katsuji, Ooigawa Hidetoshi

机构信息

Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Saitama 359-8513, Tokorozawa, Japan.

出版信息

J Clin Neurosci. 2003 May;10(3):320-4. doi: 10.1016/s0967-5868(03)00013-4.

DOI:10.1016/s0967-5868(03)00013-4

PMID:12763337

Abstract

Vascular endothelial growth factor (VEGF) is known to be a mediator of angiogenesis and vascular permeability. A cystic component and haemorrhage are often found in pituitary adenomas. We assessed the VEGF expression based on immunohistochemical examinations in 48 pituitary adenomas. All the adenomas showed some VEGF immunoreactivity mainly in the cytoplasm of tumour cells. Of the 48 adenoma-cases, 16 cases had a strong VEGF immunoreactivity, 26 cases had a moderate one, and 6 cases had a weak one. On the MR images, a cystic component was found in 16 cases (33.3%), and a haemorrhage was found in 18 cases (37.5%). The VEGF immunoreactivity had a significant relationship with the cystic component but not the haemorrhage, size, recurrence, or HE classification. These findings suggest that VEGF plays any potential role in the pathogenesis of cystic formation in pituitary adenomas.

摘要

血管内皮生长因子（VEGF）是已知的血管生成和血管通透性的介质。垂体腺瘤中常发现囊性成分和出血。我们通过免疫组织化学检查评估了48例垂体腺瘤中的VEGF表达。所有腺瘤均显示出一定程度的VEGF免疫反应性，主要位于肿瘤细胞的细胞质中。在48例腺瘤病例中，16例具有强VEGF免疫反应性，26例具有中度反应性，6例具有弱反应性。在磁共振成像（MR）上，16例（33.3%）发现有囊性成分，18例（37.5%）发现有出血。VEGF免疫反应性与囊性成分有显著关系，但与出血、大小、复发或苏木精-伊红（HE）分类无关。这些发现表明VEGF在垂体腺瘤囊性形成的发病机制中发挥了某种潜在作用。