Ibrahim F, el-Enany N
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt.
J Pharm Biomed Anal. 2003 Jun 1;32(2):353-9. doi: 10.1016/s0731-7085(02)00709-4.
The anodic polarographic behavior of ciclopirox have been studied in Britton Robinson buffer (BRb) over the pH range 6-11. In BRb of pH 7 a well defined anodic wave was produced with diffusion current constant (Id) of 4.86+/-0.048 (n=6) using DC(t) mode. Adopting both of direct current (DC(t)) and differential pulse polarographic (DPP) modes, the current-concentration relationship was found to be rectilinear over the range 4 to 24 and 2 to 12 microg ml(-1) respectively, with minimum detectability (S/N=2) of 0.2 microg ml(-1) (1 x 10(-6) M) using the DPP mode. The average percent recovery was favourably compared to a reference method, with a satisfactory standard deviation, the proposed method was further applied to the determination of ciclopirox olamine in certain pharmaceutical preparations including lotion and cream. The average percentage recoveries for lotion were 100.06+/-0.94 and 100.06+/-1.08 using DC(t) and DPP modes respectively, and for cream were 100.17+/-0.64 and 100.34+/-1.28 using DC(t) and DPP modes, respectively. A pathway for the electrode reaction was postulated.
