Weissman Tamily, Noctor Stephen C, Clinton Brian K, Honig Lawrence S, Kriegstein Arnold R
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W. 168th Street, New York, NY 10032, USA.
Cereb Cortex. 2003 Jun;13(6):550-9. doi: 10.1093/cercor/13.6.550.
Radial glial cells play at least two crucial roles in cortical development: neuronal production in the ventricular zone (VZ) and the subsequent guidance of neuronal migration. There is evidence that radial glia-like cells are present not only during development but in the adult mammalian brain as well. In addition, radial glial cells appear to be neurogenic in the central nervous system of a number of vertebrate species. We demonstrate here that most dividing progenitor cells in the embryonic human VZ express radial glial proteins. Furthermore, we provide evidence that radial glial cells maintain a vimentin-positive radial fiber throughout each stage of cell division. Asymmetric inheritance of this fiber may be an important factor in determining how neuronal progeny will migrate into the developing cortical plate. Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS.
在脑室区（VZ）产生神经元以及随后引导神经元迁移。有证据表明，放射状胶质样细胞不仅在发育过程中存在，在成年哺乳动物大脑中也存在。此外，放射状胶质细胞在许多脊椎动物物种的中枢神经系统中似乎具有神经源性。我们在此证明，胚胎人类脑室区中大多数正在分裂的祖细胞表达放射状胶质蛋白。此外，我们提供证据表明，放射状胶质细胞在细胞分裂的每个阶段都维持波形蛋白阳性的放射状纤维。这种纤维的不对称遗传可能是决定神经元后代如何迁移到发育中的皮质板的一个重要因素。尽管传统上放射状胶质细胞以其在引导迁移中的作用为特征，但它们作为神经元祖细胞的作用可能代表了它们在整个脊椎动物中枢神经系统中的决定性特征。
