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斑马鱼和哺乳动物端脑中成年神经发生与再生的共同特征和不同特征

Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.

作者信息

Diotel Nicolas, Lübke Luisa, Strähle Uwe, Rastegar Sepand

机构信息

INSERM, UMR 1188, Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), Université de La Réunion, Saint-Denis, France.

Institute of Biological and Chemical Systems-Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

出版信息

Front Neurosci. 2020 Sep 23;14:568930. doi: 10.3389/fnins.2020.568930. eCollection 2020.

DOI:10.3389/fnins.2020.568930
PMID:33071740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7538694/
Abstract

In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many similarities at the cellular and molecular level. However, upon injury during tissue repair, the situation is entirely different. In zebrafish, inflammation caused by traumatic brain injury or by induced neurodegeneration initiates specific and distinct neurogenic programs that, in combination with signaling pathways implicated in constitutive neurogenesis, quickly, and efficiently overcome the loss of neurons. In the mouse brain, injury-induced inflammation promotes gliosis leading to glial scar formation and inhibition of regeneration. A better understanding of the regenerative mechanisms occurring in the zebrafish brain could help to develop new therapies to combat the debilitating consequences of brain injury, stroke, and neurodegeneration. The aim of this review is to compare the properties of neural progenitors and the signaling pathways, which control adult neurogenesis and regeneration in the zebrafish and mammalian telencephalon.

摘要

与哺乳动物不同，成年斑马鱼的大脑在几乎所有脑区的众多微环境中都表现出神经发生活性。尽管如此，成年斑马鱼和小鼠端脑的组成性神经发生在细胞和分子水平上有许多相似之处。然而，在组织修复过程中受到损伤时，情况则完全不同。在斑马鱼中，创伤性脑损伤或诱导性神经退行性变引起的炎症会启动特定且独特的神经发生程序，这些程序与组成性神经发生所涉及的信号通路相结合，能够快速且有效地克服神经元的损失。在小鼠大脑中，损伤诱导的炎症会促进胶质增生，导致胶质瘢痕形成并抑制再生。更好地理解斑马鱼大脑中发生的再生机制，可能有助于开发新的疗法，以对抗脑损伤、中风和神经退行性变带来的使人衰弱的后果。本综述的目的是比较神经祖细胞的特性以及控制斑马鱼和哺乳动物端脑成年神经发生和再生的信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/556d/7538694/8187c39f31eb/fnins-14-568930-g008.jpg
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