Xu Qing, de la Cruz Estanislao, Anderson Stewart A
Department of Psychiatry and Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Box 244, Room 929A Lasdon, 1300 York Ave., New York, NY 10021, USA.
Cereb Cortex. 2003 Jun;13(6):670-6. doi: 10.1093/cercor/13.6.670.
GABAergic interneurons perform crucial roles in cortical development and function. These roles are executed by a diversity of interneuron subtypes, and abnormal function of particular subtypes has been implicated in a variety of neuropsychiatric diseases. However, little is known about the mechanisms that generate interneuron diversity. This paper discusses the potential origins of interneuron subtypes. Evidence is reviewed that suggests bipolar calretinin expressing interneurons may have distinct origins from those that express parvalbumin or somatostatin. In addition, evidence is presented that migratory cells from the subcortical subventricular zone (SVZ) do not proliferate after migration into the cortical SVZ.
γ-氨基丁酸能中间神经元在皮层发育和功能中发挥着关键作用。这些作用由多种中间神经元亚型执行，特定亚型的功能异常与多种神经精神疾病有关。然而，对于产生中间神经元多样性的机制知之甚少。本文讨论了中间神经元亚型的潜在起源。综述的证据表明，表达双极钙视网膜蛋白的中间神经元可能具有与表达小白蛋白或生长抑素的中间神经元不同的起源。此外，有证据表明，来自皮质下室管膜下区（SVZ）的迁移细胞在迁移到皮质SVZ后不会增殖。
