GABA 能性突触：其可塑性及其在感觉皮层中的作用。
GABAergic synapses: their plasticity and role in sensory cortex.
机构信息
SUNY Eye Research Consortium Buffalo, NY, USA ; Program in Neuroscience, SUNY - Stony Brook Stony Brook, NY, USA ; Medical Scientist Training Program, SUNY - Stony Brook Stony Brook, NY, USA.
SUNY Eye Research Consortium Buffalo, NY, USA ; Department of Neurobiology and Behavior, SUNY - Stony Brook Stony Brook, NY, USA.
出版信息
Front Cell Neurosci. 2014 Mar 26;8:91. doi: 10.3389/fncel.2014.00091. eCollection 2014.
Abstract
The mammalian neocortex is composed of a variety of cell types organized in a highly interconnected circuit. GABAergic neurons account for only about 20% of cortical neurons. However, they show widespread connectivity and a high degree of diversity in morphology, location, electrophysiological properties and gene expression. In addition, distinct populations of inhibitory neurons have different sensory response properties, capacities for plasticity and sensitivities to changes in sensory experience. In this review we summarize experimental evidence regarding the properties of GABAergic neurons in primary sensory cortex. We will discuss how distinct GABAergic neurons and different forms of GABAergic inhibitory plasticity may contribute to shaping sensory cortical circuit activity and function.
摘要
哺乳动物的新皮层由多种细胞类型组成，这些细胞类型以高度互联的回路形式组织在一起。γ-氨基丁酸能神经元仅占皮质神经元的约 20%。然而，它们在形态、位置、电生理特性和基因表达上表现出广泛的连通性和高度的多样性。此外，不同群体的抑制性神经元具有不同的感觉反应特性、可塑性能力和对感觉经验变化的敏感性。在这篇综述中，我们总结了关于初级感觉皮层中γ-氨基丁酸能神经元特性的实验证据。我们将讨论不同的γ-氨基丁酸能神经元和不同形式的γ-氨基丁酸能抑制性可塑性如何有助于塑造感觉皮层回路的活动和功能。
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