Nanaev A K, Klibaner M I
Biull Eksp Biol Med. 1976 Feb;81(2):248-50.
The authors examined serial sections of the myocardium of rats sacrificed at periods of from 1 to 24 hours after adrenalin administration. The results of histoenzymatic reaction to succinic dehydrogenase (a test for cell injury) were compared with the data obtained in fibrin detection by Coons' method. Plasmorrhagia into the irreversibly injured muscle cells had a characteristic appearance in the test with nitro-BT; there proved to be no fibrin in the fibers with fatty dystrophy marked by macrogranular depositions of formazan. A supposition was put forward on different pathogenesis of the reversible and irreversible injuries of the myocardium caused by adrenalin administration.
作者检查了在给予肾上腺素后1至24小时处死的大鼠心肌连续切片。将琥珀酸脱氢酶组织酶反应(细胞损伤检测)的结果与通过孔斯法进行纤维蛋白检测所获得的数据进行了比较。在硝基四氮唑蓝试验中,不可逆损伤的肌肉细胞出现血浆外渗的特征性表现;在以甲臜大颗粒沉积为特征的脂肪变性纤维中未发现纤维蛋白。针对肾上腺素给药引起的心肌可逆性和不可逆性损伤的不同发病机制提出了一种假设。