Saxon A, Kattlove H E
Blood. 1976 Jun;47(6):957-61.
The effects of sodium nitroprusside (N.P.), a pure smooth muscle inhibitor, on platelet function were studied. Platelet-rich plasmas (PRP) from normal controls and from patients receiving N.P. were studied in vitro for aggregation in response to adenosine diphosphate (ADP), epinephrine, and collagen. Platelet ADP release (release reaction) was also investigated. Normal platelets demonstrated marked inhibition of aggregation when incubated with N.P. for 3 min. Prolonging the incubation was without additional effect. ADP and ATP release from platelets in response to collagen was also inhibited. PRP from patients receiving nitroprusside at concentrations between 25 mug/min an 165 mug/min showed inhibition of aggregation when compared to findings prior to the administration of N.P. N.P. acts by inhibiting contractile proteins and thus platelet ADP release and aggregation may depend on contraction of platelet smooth muscle-like protein, thrombosthenin.
研究了纯平滑肌抑制剂硝普钠（N.P.）对血小板功能的影响。对来自正常对照组和接受N.P.治疗患者的富含血小板血浆（PRP）进行体外研究，观察其对二磷酸腺苷（ADP）、肾上腺素和胶原的聚集反应。同时也研究了血小板ADP释放（释放反应）。正常血小板与N.P.孵育3分钟后，聚集受到显著抑制。延长孵育时间没有额外影响。血小板对胶原的ADP和ATP释放也受到抑制。接受硝普钠治疗的患者，其浓度在25微克/分钟至165微克/分钟之间时，与使用N.P.之前的结果相比，PRP的聚集受到抑制。N.P.通过抑制收缩蛋白起作用，因此血小板ADP释放和聚集可能依赖于血小板平滑肌样蛋白血栓收缩蛋白的收缩。
