依洛前列素与硝普钠对血管平滑肌及血小板聚集的相互作用。

Interactions of iloprost and sodium nitroprusside on vascular smooth muscle and platelet aggregation.

Lidbury P S, Antunes E, de Nucci G, Vane J R

William Harvey Research Institute, St Bartholomew's Hospital Medical College, London.

Br J Pharmacol. 1989 Dec;98(4):1275-80. doi: 10.1111/j.1476-5381.1989.tb12674.x.

Abstract

The aim of the study was to assess and quantify any synergism occurring between the stable analogues of prostacyclin (iloprost) and nitric oxide (sodium nitroprusside) with respect to both relaxation of vascular smooth muscle and inhibition of platelet aggregation in the rabbit. 2. Iloprost (0.3-3 ng ml-1) and sodium nitroprusside (0.3-3 ng ml-1) caused dose-dependent relaxation of the rabbit mesenteric and coeliac arteries. 3. Iloprost (0.3-30 ng ml-1) and sodium nitroprusside (0.03-30 micrograms ml-1) caused dose-dependent inhibition of rabbit platelet aggregation induced by adenosine diphosphate or collagen. 4. In combination, iloprost and sodium nitroprusside caused an inhibition of platelet aggregation that was 2-3 fold greater than would be expected by summation, while no such potentiation was observed on vascular smooth muscle. 5. Thus, our results indicate that under physiological conditions the mediators prostacyclin and endothelium-derived relaxing factor (NO) can exert a synergistic action on platelets, but have only an additive effect on vascular smooth muscle.

摘要

本研究的目的是评估和量化前列环素（依洛前列素）和一氧化氮（硝普钠）的稳定类似物在兔血管平滑肌舒张和血小板聚集抑制方面所产生的协同作用。2. 依洛前列素（0.3 - 3纳克/毫升）和硝普钠（0.3 - 3纳克/毫升）可引起兔肠系膜动脉和腹腔动脉的剂量依赖性舒张。3. 依洛前列素（0.3 - 30纳克/毫升）和硝普钠（0.03 - 30微克/毫升）可引起对二磷酸腺苷或胶原诱导的兔血小板聚集的剂量依赖性抑制。4. 依洛前列素和硝普钠联合使用时，对血小板聚集的抑制作用比预期的相加作用大2至3倍，而在血管平滑肌上未观察到这种增强作用。5. 因此，我们的结果表明，在生理条件下，介质前列环素和内皮源性舒张因子（一氧化氮）对血小板可发挥协同作用，但对血管平滑肌仅具有相加作用。