Zhang F, Han D, Zhu X
PLA 466 Hospital, Beijing 100081.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1999 Aug;34(4):229-31.
To determine the desensitization effect of capsaicin.
Toluene-2,4-diisocyanate(TDI) sensitized white rabbits used as animal models of allergic rhinitis were treated with capsaicin. At the end of treatment, the changes in the nasal mucosa were studied by immunohistochemical and pathological methods.
Our results showed that the symptoms of allergic rhinitis were remarkably relieved after capsaicin treatment. Immunohistochemical study revealed that substance P immunoreactive fibers in the nasal mucosa showed a marked decrease after capasicin application, but the density and number of SP-IR fibers were significantly increased in the control group. Hematoxylin and eosin staining demonstrated that no edema was found in the nasal mucosa and small vessels were normal after capsaicin application, but edema, vasodilation and inflammatory cell infiltration were discovered in the control group.
The results suggested that local capsaicin treatment was a selective, and non-traumatic method to induce a long lasting desensitization of the nasal mucosa, to alleviate nasal congestion, rhinorrhea and sneezing, and to reduce the sensory neuron sensitivity of the mucosa.
确定辣椒素的脱敏效果。
将甲苯-2,4-二异氰酸酯（TDI）致敏的白兔作为变应性鼻炎动物模型，用辣椒素进行治疗。治疗结束时，采用免疫组织化学和病理学方法研究鼻黏膜的变化。
我们的结果显示，辣椒素治疗后变应性鼻炎症状明显缓解。免疫组织化学研究表明，应用辣椒素后鼻黏膜中P物质免疫反应性纤维显著减少，但对照组中SP-IR纤维的密度和数量显著增加。苏木精-伊红染色显示，应用辣椒素后鼻黏膜未发现水肿，小血管正常，但对照组出现水肿、血管扩张和炎性细胞浸润。
结果表明，局部应用辣椒素是一种选择性、非创伤性的方法，可诱导鼻黏膜产生持久的脱敏作用，减轻鼻充血、鼻漏和打喷嚏，并降低黏膜感觉神经元的敏感性。
